Other Uses
An open test inside zonisamide in vii Parkinson's disease patients had positive results, according to this 2001 report.

Metabolism
Zonisamide is metabolized mostly per CYP3A4 isoenzyme, but as well CYP3A7 and CYP3A5,

Mechanism of Action
A precise mechanism of action is non known for zonisamide. Based on datthe from Leppik, spell zonisamide can be a carbonic anhydrase inhibitor like acetazolamide, this is not one of a primary mechanisms of action, which may exist as blocking insistent firing of voltage-gated sodium channels and reduction of T-type calcium channel currents,

Side Effects
Usual side results include loss of appetite/weight loss, somnolence, urinary calculus, & lightheadedness.

Interactions with Other Medication
Zonisamide & more carbonic anhydrase inhibitors such as topiramate, furosemide, and hydrochlorothiazide have been known to interfere with amobarbital, which has led to inadequate anesthetization when you took a Wada test.

In addition, a metabolism of zonisamide is inhibited by ketoconazole, cyclosporin A miconazole, fluconazole and carbamazepine in descending order.